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Monday, May 18, 2020 | History

2 edition of Cyclophosphamide (endoxana) found in the catalog.

Cyclophosphamide (endoxana)

Gordon Hamilton Fairley

Cyclophosphamide (endoxana)

an account based on the proceedings of a symposium held at the Royal College of Surgeons of England on 4 October, 1963

by Gordon Hamilton Fairley

  • 80 Want to read
  • 24 Currently reading

Published by Wright in Bristol .
Written in English

    Subjects:
  • Cyclophosphamide -- Bibliography.,
  • Cyclophosphamide.,
  • Cyclophosphamide -- Bibliographie.

  • Edition Notes

    Bibliography: p. 171-187.

    Statementsponsored by Ward, Blenkinsop & Co., Ltd. Ed. by G. Hamilton Fairley and J.M. Simister.
    ContributionsSimister, John Michael., Ward, Blenkinsop and Company.
    The Physical Object
    Paginationxi, 200 p. :
    Number of Pages200
    ID Numbers
    Open LibraryOL19340365M

      A complete review of this entire literature is obviously not feasible nor would it be useful to a clinician or chemotherapist. Dr. Hill has prepared a comprehensive review of many of the important features of cyclophosphamide and assembled the material in abbreviated form. He has packed a lot of information into a moderate-sized book. Cyclophosphamide is a drug that is used primarily for treating several types of order to work, cyclophosphamide first is converted by the liver into two chemicals, acrolein and phosphoramide. Acrolein and phosphoramide are the active compounds, and they slow the growth of cancer cells by interfering with the actions of deoxyribonucleic acid (DNA) within the cancerous cells.

    Pregnancy. Based on mechanism of action and published reports of effects in pregnant patients or animals, drug can cause fetal harm when administered to pregnant woman; exposure to cyclophosphamide during pregnancy may cause fetal malformations, miscarriage, fetal growth retardation, and toxic effects in the newborn; drug is teratogenic and embryo-fetal toxic in mice, rats, . COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle coronavirus.

      Revision: 10/09/ Page: 2 of 5 Cyclophosphamide (hydrate) SAFETY DATA SHEET Supersedes Revision: 12/04/ Material may be irritating to the mucous membranes and upper respiratory tract. May be harmful by inhalation or skin Size: 26KB. Cyclophosphamide should be taken whole and not crushed, cut, or dissolved. If you are unable to swallow cyclophosphamide, talk to your care provider or pharmacist for possible options. o If you miss a dose of cyclophosphamide, do not. take an extra dose or two doses at one time. Simply take your next dose. at the regularly scheduled time.


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Cyclophosphamide (endoxana) by Gordon Hamilton Fairley Download PDF EPUB FB2

Cyclophosphamide does not contain any antimicrobial preservative and thus care must be taken to assure the sterility of prepared solutions. Use aseptic technique. For Direct Intravenous Injection. Reconstitute Cyclophosphamide with % Sodium Chloride Injection, USP only, using the volumes listed.

Cyclophosphamide is a cancer medication that interferes with the growth and spread of cancer cells in the body. Cyclophosphamide is used to treat several types of cancer. Cyclophosphamide is also used to treat certain cases of nephrotic syndrome (kidney disease) in children.

Cyclophosphamide may also be used for purposes not listed in this / According to the FDA, cyclophosphamide is mainly indicated for use in the treatment of malignant lymphomas stages III and IV, as designated by the Ann Arbor staging system. These may include Hodgkin and Non-Hodgkin lymphoma, lymphocytic lymphoma, small lymphocytic lymphoma, Burkitt lymphoma, and multiple myeloma.[1][2].

Cyclophosphamide is used to treat various types of cancer. It is a chemotherapy drug that works by slowing or stopping cell growth. Cyclophosphamide also works by decreasing your immune system's. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.

In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death. Cyclophosphamide is a known teratogen with significant limb abnormalities and cognitive impairment resulting from first-trimester exposure.

77 In reports of Cyclophosphamide book women treated with cyclophosphamide for breast cancer in the second and third trimesters, few pregnancy complications or congenital abnormalities are noted.

78 Among lupus patients. Cyclophosphamide can be taken with or without food, but at the same time each day, preferably in the morning followed by drinking plenty of fluid throughout the day. Cyclophosphamide should be taken whole and not crushed, cut, or dissolved.

If you are unable to swallow cyclophosphamide, talk to your care provider or pharmacist for possible options. Assess pulmonary function periodically by measuring lung volumes, breath sounds, and respiratory rate (See Appendices I, J, K).Notify physician or nursing staff immediately if patient experiences signs of pulmonary fibrosis (dry cough, dyspnea, shortness of breath, cyanosis).

Cyclophosphamide definition is - an immunosuppressive and antineoplastic agent C7H15Cl2N2O2P used especially in the treatment of lymphomas and some leukemias.

Cyclophosphamide has a molecular formula of C 7 H 15 Cl 2 N 2 O 2 P•H 2 O and a molecular weight of Cyclophosphamide is soluble in water, saline, or ethanol.

Cyclophosphamide for Injection, USP is a sterile white cake available as mg, 1 g, and 2 g strength vials. Cyclophosphamide is used to treat cancer of the ovaries, breast, blood and lymph system, and nerves (mainly in children).

Cyclophosphamide is also used for retinoblastoma (a type of eye cancer mainly in children), multiple myeloma (cancer in the bone marrow), and mycosis fungoides (tumors on the skin). Cyclophosphamide is also being studied in the treatment of other types of cancer.

More About Cyclophosphamide. Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for this drug. MedlinePlus Information on Cyclophosphamide - A lay language summary of important information about this drug that may include the.

Cyclophosphamide is the generic name of the prescription drug Cytoxan, a chemotherapy drug for people with certain cancers. It’s prescribed for non-Hodgkin lymphoma, Hodgkin lymphoma, multiple. Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer.

Cyclophosphamide therapy is associated with minor transient serum enzyme elevations and has been linked to rare cases of acute liver injury. In addition, when given in high doses as a part of a myeloablative therapy, cyclophosphamide can cause acute.

Cyclophosphamide is used as a drug to treat cancer and other medi-cal conditions. In chemotherapy, it may be used alone, but more fre-quently is used concurrently or sequentially with other anticancer drugs. Cyclophosphamide is available in the United States as or mg tablets, as an oral solution, or in a crystalline hydrate form forFile Size: KB.

Cyclophosphamide is used to treat various types of is a chemotherapy drug that works by slowing or stopping cell growth. Cyclophosphamide also works by decreasing your immune system's response to various diseases. It is used to treat a certain type of kidney disease in children after other treatments have not worked.

Cyclophosphamide may also be used for various conditions such as. Cyclophosphamide also is teratogenic, causing skeletal and central nervous system abnormalities.

60, 61 Therefore, use of effective contraception during cyclophosphamide therapy is required. Cyclophosphamide also can be excreted in breast milk, suggesting that mothers of infants should not breastfeed if cyclophosphamide therapy must be used.

60, 62Cited by:   Cyclophosphamide for Injection, USP is a sterile white powder containing cyclophosphamide and is supplied in vials for single dose use. Cyclophosphamide for Injection, USP NDC mg vial, carton of 1.

Measles, mumps and rubella vaccine, live is predicted to increase the risk of generalised infection (possibly life-threatening) when given with cyclophosphamide. Public Health England advises avoid (refer to. On MaFDA removed from the Orange Book the listings for “biological products” that have been approved in applications under section of the FD&C Act because these products are no longer “listed drugs” (see section (e)(4) of the Biologics Price Competition and Innovation Act of ).

Cyclophosphamide (CYC) is an alkylating agent that was introduced into clinical practice as a chemotherapeutic agent but has also been used to treat a number of .cyclophosphamide A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.

In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death.2,15 (%) Adapted from standard reference.

1,11 unless specified otherwise. Cardiac toxicity may occur in patients receiving high-dose -dose can be defined as 60 mg/kg daily or mg/kg over a few days. Other risk factors for developing cardiac toxicity include previousFile Size: KB.